Current Approaches to the Abnormal Toxicity Test

Mechanistic approaches and the development of alternative toxicity test methods.

A mechanism can be defined as an explanation of an observed phenomenon that explains the processes underlying the phenomenon in terms of events at lower levels of organization. A prerequisite for new, more mechanistic, approaches, which would use in vitro systems rather than conventional animal analogy models, is a strengthening of the underlying scientific basis of toxicity testing. This will ...

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

Toxicity Testing and the Toxicity Testing and the Current Situation in IRAN

Current approaches to the management of hemochromatosis.

The term hemochromatosis encompasses at least four types of genetic iron overload conditions, most of them recently distinguished from one another as a result of the identification of a series of genes related to iron metabolism. At least three of these entities (HFE hemochromatosis, juvenile hemochromatosis and transferrin receptor 2 hemochromatosis) involve systemic hepcidin deficiency as a k...

Current Approaches to the Functional Gastrointestinal Disorders

Functional gastrointestinal disorders (FGD), namely, functional gastrointestinal disorders (FGID) and irritable bowel syndrome (IBS), are always in the focus of gastroenterol-ogists, because of their polymorphic symptomatology and insufficiently defined causes and habits that influence the appearance of FGD. Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID) charact...